Distal Tubular and Proximal Tubular Necrosis in the Kidneys of Burned Patients

Distal tubular and proximal tubular necrosis in the kidneys of burned patients.

The histological pictures associated with acute renal failure following abortion, incompatible blood transfusion, crush injuries, severe trauma, blackwater fever, sulphonamide intoxication, and many other conditions including burns have been described by various writers (Bratton, 1941 ; Dunn, Gillespie, and Niven, 1941; Bywaters and Beall, 1941; Bywaters and Dible, 1942; Erb, Morgan, and Farmer...

Renal Tubular Acidosis Type 2 and 3: Proximal Renal Tubular Acidosis (pRTA) and Combined Proximal and Distal RTA in Children

Renal tubular acidosis (RTA) type 2, also called proximal renal tubular acidosis, is characterized by hyperchloremic metabolic acidosis due to impaired reabsorption of bicarbonate (HCO3) in proximal tubules. It can be due to isolated defect or part of generalized defect (Fanconi syndrome). Rickets/Osteomalacia is more common and treatment is usually difficult. RTA type 3 is designated when comb...

Distal tubular necrosis with little or no oliguria.

Acute Tubular Necrosis

A rapid rise in creatinine following periods of hypotension is most commonly due to acute tubular necrosis. In ATN, urinalysis usually shows granular casts. Urine sodium is typically high due to tubular sodium loss, concentration is typically above 30 mmol/l. The urine to plasma osmolality ratio <1:1, the ability to concentrate urine is preserved despite sodium loss. Acute Tubular Necrosis is a...

Proximal Tubular Hypertrophy and Enlarged Glomerular and Proximal Tubular Urinary Space in Obese Subjects with Proteinuria

BACKGROUND Obesity is associated with glomerular hyperfiltration, increased proximal tubular sodium reabsorption, glomerular enlargement and renal hypertrophy. A single experimental study reported an increased glomerular urinary space in obese dogs. Whether proximal tubular volume is increased in obese subjects and whether their glomerular and tubular urinary spaces are enlarged is unknown. O...